Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adip...
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model
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Author / Creator
Shen, Zekun , Wang, Weiyi , Chen, Jinxing , Chen, Bingyi , Tang, Yanan , Hou, Jiaxuan , Li, Jiayan , Liu, Shuang , Mei, Yifan , Zhang, Liwei and Lu, Shaoying
Publisher
London: BioMed Central Ltd
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Language
English
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Publisher
London: BioMed Central Ltd
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Contents
sEVs derived from hypoxic HUVECs enhanced the resistance of ADSCs to reactive oxygen species (ROS) and further improved the proangiogenic ability of ADSCs in vitro. We found that the hypoxic environment altered the composition of sEVs from HUVECs and that hypoxia increased the level of miR-486-5p in sEVs. Compared to normoxic sEVs (nsEVs), hypoxic...
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Full title
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model
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TN_cdi_doaj_primary_oai_doaj_org_article_edbeaf7c584045ba9d22a88f2bc34910
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_edbeaf7c584045ba9d22a88f2bc34910
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ISSN
1477-3155
E-ISSN
1477-3155
DOI
10.1186/s12951-022-01632-1
