Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched...
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies
About this item
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Author / Creator
Hilton, John , Gelmon, Karen , Bedard, Philippe L. , Tu, Dongsheng , Xu, Hong , Tinker, Anna V. , Goodwin, Rachel , Laurie, Scott A. , Jonker, Derek , Hansen, Aaron R. , Veitch, Zachary W. , Renouf, Daniel J. , Hagerman, Linda , Lui, Hongbo , Chen, Bingshu , Kellar, Deb , Li, Irene , Lee, Sung-Eun , Kono, Takako , Cheng, Brian Y. C. , Yap, Damian , Lai, Daniel , Beatty, Sean , Soong, John , Pritchard, Kathleen I. , Soria-Bretones, Isabel , Chen, Eric , Feilotter, Harriet , Rushton, Moira , Seymour, Lesley , Aparicio, Samuel and Cescon, David W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
CX-5461 is a G-quadruplex stabilizer that exhibits synthetic lethality in homologous recombination-deficient models. In this multicentre phase I trial in patients with solid tumors, 40 patients are treated across 10 dose levels (50–650 mg/m
2
) to determine the recommended phase II dose (primary outcome), and evaluate safety, tolerability, ph...
Alternative Titles
Full title
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies
Authors, Artists and Contributors
Author / Creator
Gelmon, Karen
Bedard, Philippe L.
Tu, Dongsheng
Xu, Hong
Tinker, Anna V.
Goodwin, Rachel
Laurie, Scott A.
Jonker, Derek
Hansen, Aaron R.
Veitch, Zachary W.
Renouf, Daniel J.
Hagerman, Linda
Lui, Hongbo
Chen, Bingshu
Kellar, Deb
Li, Irene
Lee, Sung-Eun
Kono, Takako
Cheng, Brian Y. C.
Yap, Damian
Lai, Daniel
Beatty, Sean
Soong, John
Pritchard, Kathleen I.
Soria-Bretones, Isabel
Chen, Eric
Feilotter, Harriet
Rushton, Moira
Seymour, Lesley
Aparicio, Samuel
Cescon, David W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ee095627571b4e258e1890f77d3d7597
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee095627571b4e258e1890f77d3d7597
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31199-2
