An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTR...
An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
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Author / Creator
De La Gastine, Blandine , Percevault, Soizic , Varin, Laurent , Richard, Nicolas , Fobe, Fabienne , Plaud, Benoît , Daccache, Georges , Compere, Vincent , Parienti, Jean-Jacques , Coquerel, Antoine , Loilier, Magalie , Bleyzac, Nathalie , Bourguignon, Laurent , Goutelle, Sylvain and Lelong-Boulouard, Véronique
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publisher
Switzerland: MDPI AG
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Scope and Contents
Contents
Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objective of the CYTRAM study was to investigate the value of plasma O-dT/T ratio for CYP2D6 phenotyping. E...
Alternative Titles
Full title
An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ee290fbcb63e4bc0b0972c421252562e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee290fbcb63e4bc0b0972c421252562e
Other Identifiers
ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics14102177
