Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Cellular senescence plays an important role in human diseases, including osteoporosis and osteoarthritis. Senescent cells (SCs) produce the senescence-associated secretory phenotype to affect the function of neighboring cells and SCs themselves. Delayed fracture healing is common in the elderly and is accompanied by reduced mesenchymal progenitor c...
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Full title
Age-associated callus senescent cells produce TGF-β1 that inhibits fracture healing in aged mice
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TN_cdi_doaj_primary_oai_doaj_org_article_ee5217b7a6cf42768015cc8f098d936d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee5217b7a6cf42768015cc8f098d936d
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI148073
