Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
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Author / Creator
Li, Xin , Wang, Sheng , Xie, Ying , Jiang, Hongmei , Guo, Jing , Wang, Yixuan , Peng, Ziyi , Hu, Meilin , Wang, Mengqi , Wang, Jingya , Li, Qian , Wang, Yafei and Liu, Zhiqiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Acquired chemoresistance to proteasome inhibitors is a major obstacle in managing multiple myeloma but key regulators and underlying mechanisms still remain to be explored. We find that high level of HP1γ is associated with low acetylation modification in the bortezomib-resistant myeloma cells using SILAC-based acetyl-proteomics assay, and higher H...
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Full title
Deacetylation induced nuclear condensation of HP1γ promotes multiple myeloma drug resistance
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TN_cdi_doaj_primary_oai_doaj_org_article_ee52ea271a314c128b8c65fbb8771fc3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee52ea271a314c128b8c65fbb8771fc3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-37013-x
