Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and im...
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Microsatellite-instable (MSI), a predictive biomarker for immune checkpoint blockade (ICB) response, is caused by mismatch repair deficiency (MMRd) that occurs through genetic or epigenetic silencing of MMR genes. Here, we report a mechanism of MMRd and demonstrate that protein phosphatase 2A (PP2A) deletion or inactivation converts cold microsatel...
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Full title
Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response
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TN_cdi_doaj_primary_oai_doaj_org_article_ee5d373d4c714baf8fcd6599a08ef1f1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee5d373d4c714baf8fcd6599a08ef1f1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27620-x
