A novel statistical framework for meta-analysis of total mediation effect with high-dimensional omic...
A novel statistical framework for meta-analysis of total mediation effect with high-dimensional omics mediators in large-scale genomic consortia
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Full title
Author / Creator
Xu, Zhichao and Wei, Peng
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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More information
Scope and Contents
Contents
Meta-analysis is used to aggregate the effects of interest across multiple studies, while its methodology is largely underexplored in mediation analysis, particularly in estimating the total mediation effect of high-dimensional omics mediators. Large-scale genomic consortia, such as the Trans-Omics for Precision Medicine (TOPMed) program, comprise...
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Full title
A novel statistical framework for meta-analysis of total mediation effect with high-dimensional omics mediators in large-scale genomic consortia
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Author / Creator
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TN_cdi_doaj_primary_oai_doaj_org_article_ee8d123d8b4343ac818637dcb1304e7e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee8d123d8b4343ac818637dcb1304e7e
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1011483
