Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
DNA double-strand break (DSB) signaling and repair are critical for genome integrity. They rely on highly coordinated processes including posttranslational modifications of proteins. Here we show that Pellino1 (Peli1) is a DSB-responsive ubiquitin ligase required for the accumulation of DNA damage response proteins and efficient homologous recombin...
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Full title
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks
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TN_cdi_doaj_primary_oai_doaj_org_article_ee92c7e083594457b9d565bc9efb1942
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ee92c7e083594457b9d565bc9efb1942
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09641-9
