Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
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Author / Creator
Zheng, Ziwen , Li, Guo , Cui, Chong , Wang, Fang , Wang, Xiaohan , Xu, Zhijiao , Guo, Huiping , Chen, Yuxin , Tang, Honghai , Wang, Daqi , Huang, Mingqian , Chen, Zheng-Yi , Huang, Xingxu , Li, Huawei , Li, Geng-Lin , Hu, Xiaoxiang and Shu, Yilai
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
CRISPR/RfxCas13d (CasRx) editing system can specifically and precisely cleave single-strand RNAs, which is a promising treatment for various disorders by downregulation of related gene expression. Here, we tested this RNA-editing approach on Beethoven (
Bth
) mice, an animal model for human DFNA36 due to a point mutation in
Tmc1
. We fi...
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Full title
Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing
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TN_cdi_doaj_primary_oai_doaj_org_article_eee9aef78fce4fff90a9e45b4bc297b6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eee9aef78fce4fff90a9e45b4bc297b6
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ISSN
2059-3635,2095-9907
E-ISSN
2059-3635
DOI
10.1038/s41392-022-00893-4
