ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migrat...
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
About this item
Full title
Author / Creator
Kidiyoor, Gururaj Rao , Li, Qingsen , Bastianello, Giulia , Bruhn, Christopher , Giovannetti, Irene , Mohamood, Adhil , Beznoussenko, Galina V. , Mironov, Alexandre , Raab, Matthew , Piel, Matthieu , Restuccia, Umberto , Matafora, Vittoria , Bachi, Angela , Barozzi, Sara , Parazzoli, Dario , Frittoli, Emanuela , Palamidessi, Andrea , Panciera, Tito , Piccolo, Stefano , Scita, Giorgio , Maiuri, Paolo , Havas, Kristina M. , Zhou, Zhong-Wei , Kumar, Amit , Bartek, Jiri , Wang, Zhao-Qi and Foiani, Marco
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy, electron microscopic analysis, biophysical and in vivo models, we report that ATR-defective cells exhibit altered nuclear plasticity and YAP delocalization. When subjected to mechanical stres...
Alternative Titles
Full title
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
Authors, Artists and Contributors
Author / Creator
Li, Qingsen
Bastianello, Giulia
Bruhn, Christopher
Giovannetti, Irene
Mohamood, Adhil
Beznoussenko, Galina V.
Mironov, Alexandre
Raab, Matthew
Piel, Matthieu
Restuccia, Umberto
Matafora, Vittoria
Bachi, Angela
Barozzi, Sara
Parazzoli, Dario
Frittoli, Emanuela
Palamidessi, Andrea
Panciera, Tito
Piccolo, Stefano
Scita, Giorgio
Maiuri, Paolo
Havas, Kristina M.
Zhou, Zhong-Wei
Kumar, Amit
Bartek, Jiri
Wang, Zhao-Qi
Foiani, Marco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ef3b7523ea5c4ef99f9147b73d2702d2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ef3b7523ea5c4ef99f9147b73d2702d2
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18580-9
