Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment a...
Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Kaposi’s sarcoma-associated herpesvirus (KSHV, HHV-8) is associated with several human malignancies. During latency, the viral genomes reside in the nucleus of infected cells as large non-integrated plasmids, known as episomes. To ensure episome maintenance, the latency protein LANA tethers the viral episomes to the cell chromosomes during cell div...
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Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay
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TN_cdi_doaj_primary_oai_doaj_org_article_ef60a6a045cf441d8d33a10516408850
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ef60a6a045cf441d8d33a10516408850
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1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1012972