Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric...
Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired ALL diagnosis and relapsed specimen. Targeted next generati...
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Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_ef6d2efa7bfe46babb83d0060edfc692
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ef6d2efa7bfe46babb83d0060edfc692
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42701-9
