Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
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Author / Creator
Xia, Jiliang , Zhang, Jingyu , Wu, Xuan , Du, Wanqing , Zhu, Yinghong , Liu, Xing , Liu, Zhenhao , Meng, Bin , Guo, Jiaojiao , Yang, Qin , Wang, Yihui , Wang, Qinglin , Feng, Xiangling , Xie, Guoxiang , Shen, Yi , He, Yanjuan , Xiang, Juanjuan , Wu, Minghua , An, Gang , Qiu, Lugui , Jia, Wei and Zhou, Wen
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Metabolites in the tumor microenvironment are a critical factor for tumor progression. However, the lack of knowledge about the metabolic profile in the bone marrow (BM) microenvironment of multiple myeloma (MM) limits our understanding of MM progression. Here, we show that the glycine concentration in the BM microenvironment is elevated due to bon...
Alternative Titles
Full title
Blocking glycine utilization inhibits multiple myeloma progression by disrupting glutathione balance
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ef6ec5c2a5274ceba7416ff777f570e6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ef6ec5c2a5274ceba7416ff777f570e6
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31248-w
