EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hype...
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Histone methyltransferases EZH1 and EZH2 catalyse the trimethylation of histone H3 at lysine 27 (H3K27), which serves as an epigenetic signal for chromatin condensation and transcriptional repression. Genome-wide associated studies have implicated
EZH2
in the control of height and mutations in
EZH2
cause Weaver syndrome, which includes...
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Full title
EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
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TN_cdi_doaj_primary_oai_doaj_org_article_efa3d063166f4765ab0158eaae143a1b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_efa3d063166f4765ab0158eaae143a1b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13685
