The intracellular domain of major histocompatibility class-I proteins is essential for maintaining e...
The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. However, the mechanisms by which MHC-I functions in the CNS remains unknown. Here we describe the first structural analysis of a MHC-I protein, to resolve underlying mechanisms that explains its function in the brain. We demo...
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The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain
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TN_cdi_doaj_primary_oai_doaj_org_article_efb7fabefb7e4b9fb5bff7fbd1571479
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_efb7fabefb7e4b9fb5bff7fbd1571479
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-30054-8
