Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved agi...
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
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Author / Creator
Yang, Lu , Ma, Zaijun , Wang, Han , Niu, Kongyan , Cao, Ye , Sun, Le , Geng, Yang , Yang, Bo , Gao, Feng , Chen, Zuolong , Wu, Zhen , Li, Qingqing , Shen, Yong , Zhang, Xumin , Jiang, Hong , Chen, Yelin , Liu, Rui , Liu, Nan and Zhang, Yaoyang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The long-lived proteome constitutes a pool of exceptionally stable proteins with limited turnover. Previous studies on ubiquitin-mediated protein degradation primarily focused on relatively short-lived proteins; how ubiquitylation modifies the long-lived proteome and its regulatory effect on adult lifespan is unclear. Here we profile the age-depend...
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Full title
Ubiquitylome study identifies increased histone 2A ubiquitylation as an evolutionarily conserved aging biomarker
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TN_cdi_doaj_primary_oai_doaj_org_article_f03d59fd69bc4bcba96f8c0cd012a7b5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f03d59fd69bc4bcba96f8c0cd012a7b5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10136-w
