ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors throu...
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
About this item
Full title
Author / Creator
Cao, Yu , Trillo-Tinoco, Jimena , Sierra, Rosa A. , Anadon, Carmen , Dai, Wenjie , Mohamed, Eslam , Cen, Ling , Costich, Tara L. , Magliocco, Anthony , Marchion, Douglas , Klar, Richard , Michel, Sven , Jaschinski, Frank , Reich, Richard R. , Mehrotra, Shikhar , Cubillos-Ruiz, Juan R. , Munn, David H. , Conejo-Garcia, Jose R. and Rodriguez, Paulo C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Understanding the intrinsic mediators that render CD8
+
T cells dysfunctional in the tumor microenvironment is a requirement to develop more effective cancer immunotherapies. Here, we report that C/EBP homologous protein (Chop), a downstream sensor of severe endoplasmic reticulum (ER) stress, is a major negative regulator of the effector func...
Alternative Titles
Full title
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Authors, Artists and Contributors
Author / Creator
Trillo-Tinoco, Jimena
Sierra, Rosa A.
Anadon, Carmen
Dai, Wenjie
Mohamed, Eslam
Cen, Ling
Costich, Tara L.
Magliocco, Anthony
Marchion, Douglas
Klar, Richard
Michel, Sven
Jaschinski, Frank
Reich, Richard R.
Mehrotra, Shikhar
Cubillos-Ruiz, Juan R.
Munn, David H.
Conejo-Garcia, Jose R.
Rodriguez, Paulo C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f05c7d9780cc4100b5638fc324c1bb21
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f05c7d9780cc4100b5638fc324c1bb21
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-09263-1
