Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Transposon-encoded IscB family proteins are RNA-guided nucleases in the OMEGA (obligate mobile element-guided activity) system, and likely ancestors of the RNA-guided nuclease Cas9 in the type II CRISPR-Cas adaptive immune system. IscB associates with its cognate ωRNA to form a ribonucleoprotein complex that cleaves double-stranded DNA targets comp...
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Structure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
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TN_cdi_doaj_primary_oai_doaj_org_article_f0ba686eba53416aba3c9403c2e20cc5
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f0ba686eba53416aba3c9403c2e20cc5
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-34378-3
