Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatoce...
Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis
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Author / Creator
Liu, Xinxin , Zhang, Xiaoli , Peng, Zhiqiang , Li, Chunnan , Wang, Ze , Wang, Chanjuan , Deng, Zhikang , Wu, Bo , Cui, Yu , Wang, Zhanxin , Cui, Chun‐Ping , Zheng, Min and Zhang, Lingqiang
Publisher
Germany: John Wiley & Sons, Inc
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Language
English
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Publisher
Germany: John Wiley & Sons, Inc
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Contents
Hypoxia inducible factors (HIFs) are the key transcription factors that allow cancer cells to survive hypoxia. HIF's stability is mainly controlled by von Hippel–Lindau (pVHL)‐mediated ubiquitylation. Unlike sporadic clear‐cell renal carcinomas, VHL mutation is rarely observed in hepatocellular carcinoma (HCC) and the regulatory mechanisms of pVHL‐...
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Full title
Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_f11da0b242b14da2a199ae41db0d507b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f11da0b242b14da2a199ae41db0d507b
Other Identifiers
ISSN
2198-3844
E-ISSN
2198-3844
DOI
10.1002/advs.201902040
