Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine...
Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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Strict L-chiral rejection through Gly-cisPro motif during chiral proofreading underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discriminate between D-amino acids and achiral glycine. The consequent Gly-tRNAGly ‘misediting paradox’ is resolved by EF-Tu in the cell. Here, we show that DTD’s active site architecture can efficiently edit...
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Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS
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TN_cdi_doaj_primary_oai_doaj_org_article_f174037f4e1c43b5bb0f0d9f0bb87cbd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f174037f4e1c43b5bb0f0d9f0bb87cbd
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.24001
