A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the X-linked methyl-CpG binding protein 2 (MeCP2) gene. While MeCP2 mutations are lethal in most males, females survive birth but show severe neurological defects. Because X-chromosome inactivation (XCI) is a random process, approximately 50% of the cells silence the wild-t...
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A small-molecule screen reveals novel modulators of MeCP2 and X-chromosome inactivation maintenance
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TN_cdi_doaj_primary_oai_doaj_org_article_f1d6c74a535f4002b4d27d4a54f485ae
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f1d6c74a535f4002b4d27d4a54f485ae
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ISSN
1866-1947
E-ISSN
1866-1955
DOI
10.1186/s11689-020-09332-3
