Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mi...
Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Human mesenchymal stromal cells (hMSCs) are a promising source for engineered cell-based therapies in which genetic engineering could enhance therapeutic efficacy and install novel cellular functions. Here, we describe an optimized Cas9-AAV6-based genome editing tool platform for site-specific mutagenesis and integration of up to more than 3 kiloba...
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Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice
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TN_cdi_doaj_primary_oai_doaj_org_article_f1e0b2e3490d49f9b4d885258b1c4088
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f1e0b2e3490d49f9b4d885258b1c4088
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16065-3
