A Cas-embedding strategy for minimizing off-target effects of DNA base editors
A Cas-embedding strategy for minimizing off-target effects of DNA base editors
About this item
Full title
Author / Creator
Liu, Yajing , Zhou, Changyang , Huang, Shisheng , Dang, Lu , Wei, Yu , He, Jun , Zhou, Yingsi , Mao, Shaoshuai , Tao, Wanyu , Zhang, Yu , Yang, Hui , Huang, Xingxu and Chi, Tian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
DNA base editors, typically comprising editing enzymes fused to the N-terminus of nCas9, display off-target effects on DNA and/or RNA, which have remained an obstacle to their clinical applications. Off-target edits are typically countered via rationally designed point mutations, but the approach is tedious and not always effective. Here, we report...
Alternative Titles
Full title
A Cas-embedding strategy for minimizing off-target effects of DNA base editors
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f1fdbef8038d4a33ade4dc6a223c19e3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f1fdbef8038d4a33ade4dc6a223c19e3
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19690-0
