Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophage...
Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability but their evolution has not been investigated. Here we apply multi-region exome sequencing (MSeq...
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Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_f202e0a95a5045ca81301d8ebb687ecf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f202e0a95a5045ca81301d8ebb687ecf
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13915-7
