Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resi...
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes
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Author / Creator
Gautheron, Jérémie , Lima, Lara , Akinci, Baris , Zammouri, Jamila , Auclair, Martine , Ucar, Sema Kalkan , Ozen, Samim , Altay, Canan , Bax, Bridget E , Nemazanyy, Ivan , Lenoir, Véronique , Prip-Buus, Carina , Acquaviva-Bourdain, Cécile , Lascols, Olivier , Fève, Bruno , Vigouroux, Corinne , Noel, Esther and Jéru, Isabelle
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2'-deoxyuridine, to thymine and uracil. Biallelic TYMP variants are responsible for Mitochondrial NeuroGastroIntestinal Encephalomyopathy (MNGIE), an...
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Full title
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes
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TN_cdi_doaj_primary_oai_doaj_org_article_f23ef112e8e2444f9f3eb4e619a1fccc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f23ef112e8e2444f9f3eb4e619a1fccc
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ISSN
1741-7015
E-ISSN
1741-7015
DOI
10.1186/s12916-022-02296-2
