New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R a...
New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity
About this item
Full title
Author / Creator
Talianová, Veronika , Kejík, Zdeněk , Kaplánek, Robert , Veselá, Kateřina , Abramenko, Nikita , Lacina, Lukáš , Strnadová, Karolína , Dvořánková, Barbora , Martásek, Pavel , Masařík, Michal , Megová, Magdalena Houdová , Bušek, Petr , Křížová, Jana , Zdražilová, Lucie , Hansíková, Hana , Vlčák, Erik , Filimonenko, Vlada , Šedo, Aleksi , Smetana, Karel and Jakubek, Milan
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Basel: MDPI AG
Subjects
More information
Scope and Contents
Contents
IL-6 signaling is involved in the pathogenesis of a number of serious diseases, including chronic inflammation and cancer. Targeting of IL-6 receptor (IL-6R) by small molecules is therefore an intensively studied strategy in cancer treatment. We describe the design, synthesis, and characteristics of two new bis-pentamethinium salts 5 and 6 (meta an...
Alternative Titles
Full title
New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting Activity
Authors, Artists and Contributors
Author / Creator
Kejík, Zdeněk
Kaplánek, Robert
Veselá, Kateřina
Abramenko, Nikita
Lacina, Lukáš
Strnadová, Karolína
Dvořánková, Barbora
Martásek, Pavel
Masařík, Michal
Megová, Magdalena Houdová
Bušek, Petr
Křížová, Jana
Zdražilová, Lucie
Hansíková, Hana
Vlčák, Erik
Filimonenko, Vlada
Šedo, Aleksi
Smetana, Karel
Jakubek, Milan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f251712b9341489a865b0ae337bc3d58
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f251712b9341489a865b0ae337bc3d58
Other Identifiers
ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics14081712
