MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors
MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors
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Author / Creator
Chen, Si , Hou, Jiakai , Jaffery, Roshni , Guerrero, Ashley , Fu, Rongjie , Shi, Leilei , Zheng, Ningbo , Bohat, Ritu , Egan, Nicholas A , Yu, Chengtai , Sharif, Sana , Lu, Yue , He, Wei , Wang, Shuyue , Gjuka, Donjeta , Stone, Everett M , Shah, Pooja Anil , Rodon Ahnert, Jordi , Chen, Taiping , Liu, Xinli , Bedford, Mark T , Xu, Han and Peng, Weiyi
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
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Publication information
Publisher
England: BMJ Publishing Group Ltd
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Contents
BackgroundHyperactivated protein arginine methyltransferases (PRMTs) are implicated in human cancers. Inhibiting tumor intrinsic PRMT5 was reported to potentiate antitumor immune responses, highlighting the possibility of combining PRMT5 inhibitors (PRMT5i) with cancer immunotherapy. However, global suppression of PRMT5 activity impairs the effecto...
Alternative Titles
Full title
MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors
Authors, Artists and Contributors
Author / Creator
Hou, Jiakai
Jaffery, Roshni
Guerrero, Ashley
Fu, Rongjie
Shi, Leilei
Zheng, Ningbo
Bohat, Ritu
Egan, Nicholas A
Yu, Chengtai
Sharif, Sana
Lu, Yue
He, Wei
Wang, Shuyue
Gjuka, Donjeta
Stone, Everett M
Shah, Pooja Anil
Rodon Ahnert, Jordi
Chen, Taiping
Liu, Xinli
Bedford, Mark T
Xu, Han
Peng, Weiyi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f2ce79b83742456784a1825a87418410
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f2ce79b83742456784a1825a87418410
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2024-009600
