Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal...
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To determine the fate of aneuploid cells and the developmental potential of mosaic embryos, here we generate a mouse model of chromosome mosaicism. By treating embryos with a spindle assembly checkpoint inhibitor during the four- to eight-cell division, we efficiently g...
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Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
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TN_cdi_doaj_primary_oai_doaj_org_article_f312396394384d1dacdd38a6e94d0540
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f312396394384d1dacdd38a6e94d0540
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11165
