HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
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Author / Creator
Holland, Petter , Knævelsrud, Helene , Søreng, Kristiane , Mathai, Benan J. , Lystad, Alf Håkon , Pankiv, Serhiy , Bjørndal, Gunnveig T. , Schultz, Sebastian W. , Lobert, Viola H. , Chan, Robin B. , Zhou, Bowen , Liestøl, Knut , Carlsson, Sven R. , Melia, Thomas J. , Di Paolo, Gilbert and Simonsen, Anne
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in zebrafish. HS1BP3 is localized to ATG16L1- and ATG9-...
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Full title
HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
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TN_cdi_doaj_primary_oai_doaj_org_article_f353cc30440843249f823e8e4c1b2f7c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f353cc30440843249f823e8e4c1b2f7c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13889
