Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization m...
Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model
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Author / Creator
Carbonaro, Marisa , Lee, Jeffrey , Pefanis, Evangelos , Desclaux, Mathieu , Wang, Kehui , Pennington, Alexander , Huang, Hui , Mujica, Alejo , Rojas, Jose , Ally, Roxanne , Kennedy, Daniel , Brown, Michael , Rogulin, Vitaliy , Moller-Tank, Sven , Sabin, Leah , Zambrowicz, Brian , Thurston, Gavin and Li, Zhe
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Humanized liver rodent models, in which the host liver parenchyma is repopulated by human hepatocytes, have been increasingly used for drug development and disease research. Unlike the leading humanized liver mouse model in which Fumarylacetoacetate Hydrolase (Fah), Recombination Activating Gene (Rag)-2 and Interleukin-2 Receptor Gamma (Il2rg) gene...
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Full title
Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model
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TN_cdi_doaj_primary_oai_doaj_org_article_f36f9f2973d74161ab4380d6be2edfb7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f36f9f2973d74161ab4380d6be2edfb7
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-18119-6
