A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate...
A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
About this item
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Publisher
England: International Union of Crystallography
Journal title
Language
English
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Publisher
England: International Union of Crystallography
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Scope and Contents
Contents
To protect viral DNA against the host bacterial restriction system, bacteriophages utilize a special modification system – hydroxymethylation – in which dCMP hydroxymethylase (dCH) converts dCMP to 5-hydroxymethyl-dCMP (5hm-dCMP) using
N
5,
N
10-methylenetetrahydrofolate as a cofactor. Despite shared similarity with thymidylate synthase...
Alternative Titles
Full title
A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate
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TN_cdi_doaj_primary_oai_doaj_org_article_f37ee44c31f14ce3aae92b7601be61ca
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f37ee44c31f14ce3aae92b7601be61ca
Other Identifiers
ISSN
2052-2525
E-ISSN
2052-2525
DOI
10.1107/S2052252518018274
