Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Chemotherapy is a powerful means of cancer treatment but its efficacy is compromised by the emergence of multidrug resistance (MDR), mainly linked to the efflux transporter ABCB1/P-glycoprotein (P-gp). Based on the chemical structure of betulin, identified in our previous work as an effective modulator of the P-gp function, a series of analogs were...
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Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein
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TN_cdi_doaj_primary_oai_doaj_org_article_f381725f2d524faaa32d931396d88f23
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f381725f2d524faaa32d931396d88f23
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-49939-9
