The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
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Author / Creator
Fischer, Katrin , Fenzl, Anna , Liu, Dianxin , Dyar, Kenneth A. , Kleinert, Maximilian , Brielmeier, Markus , Clemmensen, Christoffer , Fedl, Anna , Finan, Brian , Gessner, Andre , Jastroch, Martin , Huang, Jianfeng , Keipert, Susanne , Klingenspor, Martin , Brüning, Jens C. , Kneilling, Manfred , Maier, Florian C. , Othman, Ahmed E. , Pichler, Bernd J. , Pramme-Steinwachs, Ines , Sachs, Stephan , Scheideler, Angelika , Thaiss, Wolfgang M. , Uhlenhaut, Henriette , Ussar, Siegfried , Woods, Stephen C. , Zorn, Julia , Stemmer, Kerstin , Collins, Sheila , Diaz-Meco, Maria , Moscat, Jorge , Tschöp, Matthias H. and Müller, Timo D.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of
Ucp1
and
Pgc-1α
. The mechanisms underlying ATF2 target activation are unknown. Here we demonstrate that p62 (Sqstm1) binds to ATF2 to orchest...
Alternative Titles
Full title
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
Authors, Artists and Contributors
Author / Creator
Fenzl, Anna
Liu, Dianxin
Dyar, Kenneth A.
Kleinert, Maximilian
Brielmeier, Markus
Clemmensen, Christoffer
Fedl, Anna
Finan, Brian
Gessner, Andre
Jastroch, Martin
Huang, Jianfeng
Keipert, Susanne
Klingenspor, Martin
Brüning, Jens C.
Kneilling, Manfred
Maier, Florian C.
Othman, Ahmed E.
Pichler, Bernd J.
Pramme-Steinwachs, Ines
Sachs, Stephan
Scheideler, Angelika
Thaiss, Wolfgang M.
Uhlenhaut, Henriette
Ussar, Siegfried
Woods, Stephen C.
Zorn, Julia
Stemmer, Kerstin
Collins, Sheila
Diaz-Meco, Maria
Moscat, Jorge
Tschöp, Matthias H.
Müller, Timo D.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f38460b423054ee680f7224c62a860c9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f38460b423054ee680f7224c62a860c9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16230-8
