Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related...
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
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Publisher
England: BioMed Central
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English
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England: BioMed Central
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One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD and has been shown to influence the accumulation of Aβ in the brain in an isoform-dependent manner. ApoE can be produced by di...
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Full title
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
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TN_cdi_doaj_primary_oai_doaj_org_article_f3a88e4afff14cb6a4fc4d21da89f36f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3a88e4afff14cb6a4fc4d21da89f36f
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-022-00516-0
