Application of RNAi Technology in Cancer Therapy.
Application of RNAi Technology in Cancer Therapy.
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Publisher
China: Chinese Anti-Cancer Association Chinese Antituberculosis Association
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Scope and Contents
Contents
RNA干扰(RNA interference, RNAi)是近年发现的一种重要的基因表达调控方式,是由转入细胞的小干扰双链RNA诱导同源mRNA特异性降解产生的一种转录后基因沉默现象(post transcription gene silencing, PTGS)。RNAi技术随着细胞生物学、分子生物学、分子遗传学、免疫学等相关学科的迅猛发展,在理论和技术上已趋成熟, 已从实验及基础研究过渡到临床试用阶段。同其它肿瘤治疗手段相比,RNAi技术的主要优势在于其主要针对致病的相关基因起作用,特异性下调相关基因的表达以达到治疗的目的。目前在体内实现RNAi的两种常用方式是为利用病毒载体表达短的发夹状RNA(short hairpin, shRNA)以及化学合成的小干扰RNA(small inter...
Alternative Titles
Full title
Application of RNAi Technology in Cancer Therapy.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f3a9e04d626248c097d50dbf9e69a698
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3a9e04d626248c097d50dbf9e69a698
Other Identifiers
ISSN
1009-3419
E-ISSN
1999-6187
DOI
10.3779/j.issn.1009-3419.2009.07.012