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Application of RNAi Technology in Cancer Therapy.

Application of RNAi Technology in Cancer Therapy.

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3a9e04d626248c097d50dbf9e69a698

Application of RNAi Technology in Cancer Therapy.

About this item

Full title

Application of RNAi Technology in Cancer Therapy.

Author / Creator

Publisher

China: Chinese Anti-Cancer Association Chinese Antituberculosis Association

Journal title

Zhongguo fei ai za zhi, 2009-07, Vol.12 (7), p.811-815

Language

Chinese

Formats

Publication information

Publisher

China: Chinese Anti-Cancer Association Chinese Antituberculosis Association

More information

Scope and Contents

Contents

RNA干扰(RNA interference, RNAi)是近年发现的一种重要的基因表达调控方式,是由转入细胞的小干扰双链RNA诱导同源mRNA特异性降解产生的一种转录后基因沉默现象(post transcription gene silencing, PTGS)。RNAi技术随着细胞生物学、分子生物学、分子遗传学、免疫学等相关学科的迅猛发展,在理论和技术上已趋成熟, 已从实验及基础研究过渡到临床试用阶段。同其它肿瘤治疗手段相比,RNAi技术的主要优势在于其主要针对致病的相关基因起作用,特异性下调相关基因的表达以达到治疗的目的。目前在体内实现RNAi的两种常用方式是为利用病毒载体表达短的发夹状RNA(short hairpin, shRNA)以及化学合成的小干扰RNA(small inter...

Alternative Titles

Full title

Application of RNAi Technology in Cancer Therapy.

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_f3a9e04d626248c097d50dbf9e69a698

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3a9e04d626248c097d50dbf9e69a698

Other Identifiers

ISSN

1009-3419

E-ISSN

1999-6187

DOI

10.3779/j.issn.1009-3419.2009.07.012

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