Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the RIIβ holoenzyme as a prototype, we show how autophosphorylation/dephosphorylation of the RIIβ subunit, as well as cAMP and metal ions, c...
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Full title
Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme
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TN_cdi_doaj_primary_oai_doaj_org_article_f3af226096054bbfacdf5c8046e4a3ce
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3af226096054bbfacdf5c8046e4a3ce
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1002192
