The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition a...
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
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England: BioMed Central Ltd
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English
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Publisher
England: BioMed Central Ltd
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We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells.
FLLL32 specifically reduced STAT3 phosphorylation at Tyr705 (pSTAT3) and induce...
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The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity
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TN_cdi_doaj_primary_oai_doaj_org_article_f3aff333fbda4d3d8d697c842c935fd4
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3aff333fbda4d3d8d697c842c935fd4
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/1476-4598-9-165
