HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking selectivity for IN tetramers versus lower order protein oligomers. IN structural features that are...
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Full title
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_f3f96045b25c4b55a0b26306772c43fd
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f3f96045b25c4b55a0b26306772c43fd
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.46344
