Gene editing and elimination of latent herpes simplex virus in vivo
Gene editing and elimination of latent herpes simplex virus in vivo
About this item
Full title
Author / Creator
Aubert, Martine , Strongin, Daniel E. , Roychoudhury, Pavitra , Loprieno, Michelle A. , Haick, Anoria K. , Klouser, Lindsay M. , Stensland, Laurence , Huang, Meei-Li , Makhsous, Negar , Tait, Alexander , De Silva Feelixge, Harshana S. , Galetto, Roman , Duchateau, Philippe , Greninger, Alexander L. , Stone, Daniel and Jerome, Keith R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a potentially curative approach to treat latent HSV infection. Here we show that AAV-delivered meganucleases, but not CRISPR/Cas9, mediate highly efficient gene editing of HSV, eliminating over 90% of latent virus from s...
Alternative Titles
Full title
Gene editing and elimination of latent herpes simplex virus in vivo
Authors, Artists and Contributors
Author / Creator
Strongin, Daniel E.
Roychoudhury, Pavitra
Loprieno, Michelle A.
Haick, Anoria K.
Klouser, Lindsay M.
Stensland, Laurence
Huang, Meei-Li
Makhsous, Negar
Tait, Alexander
De Silva Feelixge, Harshana S.
Galetto, Roman
Duchateau, Philippe
Greninger, Alexander L.
Stone, Daniel
Jerome, Keith R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f4d037a80a34400ba2411e4046361719
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f4d037a80a34400ba2411e4046361719
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17936-5
