Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide...
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
About this item
Full title
Author / Creator
Latina, Valentina , Giacovazzo, Giacomo , Cordella, Federica , Balzamino, Bijorn Omar , Micera, Alessandra , Varano, Monica , Marchetti, Cristina , Malerba, Francesca , Florio, Rita , Ercole, Bruno Bruni , La Regina, Federico , Atlante, Anna , Coccurello, Roberto , Di Angelantonio, Silvia , Calissano, Pietro and Amadoro, Giuseppina
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of synapses, visual deficits, loss of retinal cells and nerve fi...
Alternative Titles
Full title
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
Authors, Artists and Contributors
Author / Creator
Giacovazzo, Giacomo
Cordella, Federica
Balzamino, Bijorn Omar
Micera, Alessandra
Varano, Monica
Marchetti, Cristina
Malerba, Francesca
Florio, Rita
Ercole, Bruno Bruni
La Regina, Federico
Atlante, Anna
Coccurello, Roberto
Di Angelantonio, Silvia
Calissano, Pietro
Amadoro, Giuseppina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f4f21a46b50649418d3a63b51e6c1fe6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f4f21a46b50649418d3a63b51e6c1fe6
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01138-1
