Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates...
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Scope and Contents
Contents
Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer's disease (AD) and frontotemporal dementia (FTD). Tau
, an epitope in the truncated tau, is essential for pathological tau-tau interaction and aggregation. A tau
-targeted approach may have beneficial effects in the treatment of AD and FTD.
In thi...
Alternative Titles
Full title
Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f50953cb30a846db91d8dca212459126
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f50953cb30a846db91d8dca212459126
Other Identifiers
ISSN
1758-9193
E-ISSN
1758-9193
DOI
10.1186/s13195-018-0378-7
