Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice...
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease
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Cairo, Egypt: Hindawi Publishing Corporation
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English
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Cairo, Egypt: Hindawi Publishing Corporation
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Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regulate inflammatory gene transcription. We show that BET inhibition by the small molecule apabetalone r...
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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease
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TN_cdi_doaj_primary_oai_doaj_org_article_f51d93da11054162b5cd4b953f4b5169
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f51d93da11054162b5cd4b953f4b5169
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ISSN
1755-5914
E-ISSN
1755-5922
DOI
10.1155/2020/9397109
