Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces depend...
Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
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England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Inhibitors of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD
biosynthesis from nicotinamide, exhibit anticancer effects in preclinical models. However, continuous exposure to NAMPT inhibitors, such as FK866, can induce acquired resistance.
We developed FK866-resistant CCRF-CEM (T cell acute lymphoblastic leuke...
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Full title
Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA
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TN_cdi_doaj_primary_oai_doaj_org_article_f5728adb11c248ac9fb0d53b1864298d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f5728adb11c248ac9fb0d53b1864298d
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ISSN
2049-3002
E-ISSN
2049-3002
DOI
10.1186/s40170-018-0174-7
