Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Su...
Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Subunits in the Shaky Mouse Model of Startle Disease
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Switzerland: Frontiers Research Foundation
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Language
English
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Switzerland: Frontiers Research Foundation
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Contents
Mutations in GlyR α1 or β subunit genes in humans and rodents lead to severe startle disease characterized by rigidity, massive stiffness and excessive startle responses upon unexpected tactile or acoustic stimuli. The recently characterized startle disease mouse mutant
carries a missense mutation (Q177K) in the β8-β9 loop within the large extra...
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Full title
Functional Consequences of the Postnatal Switch From Neonatal to Mutant Adult Glycine Receptor α1 Subunits in the Shaky Mouse Model of Startle Disease
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TN_cdi_doaj_primary_oai_doaj_org_article_f5d80e63d5444f989867a5cb27d9b8fc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f5d80e63d5444f989867a5cb27d9b8fc
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ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2018.00167
