Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure...
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
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Author / Creator
Human Kidney Tissue Resource Study Group , Xu, Xiaoguang , Khunsriraksakul, Chachrit , Eales, James M. , Rubin, Sebastien , Scannali, David , Saluja, Sushant , Talavera, David , Markus, Havell , Wang, Lida , Drzal, Maciej , Maan, Akhlaq , Lay, Abigail C. , Prestes, Priscilla R. , Regan, Jeniece , Diwadkar, Avantika R. , Denniff, Matthew , Rempega, Grzegorz , Ryszawy, Jakub , Król, Robert , Dormer, John P. , Szulinska, Monika , Walczak, Marta , Antczak, Andrzej , Matías-García, Pamela R. , Waldenberger, Melanie , Woolf, Adrian S. , Keavney, Bernard , Zukowska-Szczechowska, Ewa , Wystrychowski, Wojciech , Zywiec, Joanna , Bogdanski, Pawel , Danser, A. H. Jan , Samani, Nilesh J. , Guzik, Tomasz J. , Morris, Andrew P. , Liu, Dajiang J. , Charchar, Fadi J. and Tomaszewski, Maciej
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-wide association studies in 700 human kidneys. We identified 889 kidney genes associated with BP of which 399...
Alternative Titles
Full title
Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
Authors, Artists and Contributors
Author / Creator
Xu, Xiaoguang
Khunsriraksakul, Chachrit
Eales, James M.
Rubin, Sebastien
Scannali, David
Saluja, Sushant
Talavera, David
Markus, Havell
Wang, Lida
Drzal, Maciej
Maan, Akhlaq
Lay, Abigail C.
Prestes, Priscilla R.
Regan, Jeniece
Diwadkar, Avantika R.
Denniff, Matthew
Rempega, Grzegorz
Ryszawy, Jakub
Król, Robert
Dormer, John P.
Szulinska, Monika
Walczak, Marta
Antczak, Andrzej
Matías-García, Pamela R.
Waldenberger, Melanie
Woolf, Adrian S.
Keavney, Bernard
Zukowska-Szczechowska, Ewa
Wystrychowski, Wojciech
Zywiec, Joanna
Bogdanski, Pawel
Danser, A. H. Jan
Samani, Nilesh J.
Guzik, Tomasz J.
Morris, Andrew P.
Liu, Dajiang J.
Charchar, Fadi J.
Tomaszewski, Maciej
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f5e9da19c88d4024b4071ce5130ced06
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f5e9da19c88d4024b4071ce5130ced06
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-46132-y
