The structural basis of the activation and inhibition of DSR2 NADase by phage proteins
The structural basis of the activation and inhibition of DSR2 NADase by phage proteins
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Author / Creator
Wang, Ruiwen , Xu, Qi , Wu, Zhuoxi , Li, Jialu , Guo, Hao , Liao, Tianzhui , Shi, Yuan , Yuan, Ling , Gao, Haishan , Yang, Rong , Shi, Zhubing and Li, Faxiang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
DSR2, a Sir2 domain-containing protein, protects bacteria from phage infection by hydrolyzing NAD
+
. The enzymatic activity of DSR2 is triggered by the SPR phage tail tube protein (TTP), while suppressed by the SPbeta phage-encoded DSAD1 protein, enabling phages to evade the host defense. However, the molecular mechanisms of activation and i...
Alternative Titles
Full title
The structural basis of the activation and inhibition of DSR2 NADase by phage proteins
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TN_cdi_doaj_primary_oai_doaj_org_article_f621a36bd7954d38a4dca7061bf848a7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f621a36bd7954d38a4dca7061bf848a7
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50410-0
