Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in h...
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
About this item
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Author / Creator
Li, Ning , Kalyanasundaram, Anuradha , Hansen, Brian J. , Artiga, Esthela J. , Sharma, Roshan , Abudulwahed, Suhaib H. , Helfrich, Katelynn M. , Rozenberg, Galina , Wu, Pei-Jung , Zakharkin, Stanislav , Gyorke, Sandor , Janssen, Paul ML , Whitson, Bryan A. , Mokadam, Nahush A. , Biesiadecki, Brandon J. , Accornero, Federica , Hummel, John D. , Mohler, Peter J. , Dobrzynski, Halina , Zhao, Jichao and Fedorov, Vadim V.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution optical mapping in explanted human hearts depress intranodal SAN condu...
Alternative Titles
Full title
Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node
Authors, Artists and Contributors
Author / Creator
Kalyanasundaram, Anuradha
Hansen, Brian J.
Artiga, Esthela J.
Sharma, Roshan
Abudulwahed, Suhaib H.
Helfrich, Katelynn M.
Rozenberg, Galina
Wu, Pei-Jung
Zakharkin, Stanislav
Gyorke, Sandor
Janssen, Paul ML
Whitson, Bryan A.
Mokadam, Nahush A.
Biesiadecki, Brandon J.
Accornero, Federica
Hummel, John D.
Mohler, Peter J.
Dobrzynski, Halina
Zhao, Jichao
Fedorov, Vadim V.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f630452532e74b488261b252cd5af083
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f630452532e74b488261b252cd5af083
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-14039-8
