Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumoniae: pharmacok...
Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumoniae: pharmacokinetics-pharmacodynamics combined with transcriptomic approach
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
The aim of this study was to identify the synergistic effect and mechanisms of fosfomycin (FM) combined with colistin (COL) against KPC-producing Klebsiella pneumoniae (KPC-Kp).
The bactericidal effects, induced drug resistance and cytotoxicity of FM combined with COL were evaluated by time-kill assays and mutation rate test. Time-kill assays an...
Alternative Titles
Full title
Synergistic effect of fosfomycin and colistin against KPC-producing Klebsiella pneumoniae: pharmacokinetics-pharmacodynamics combined with transcriptomic approach
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TN_cdi_doaj_primary_oai_doaj_org_article_f641856f76554778a808599e56c94376
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f641856f76554778a808599e56c94376
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ISSN
1471-2180
E-ISSN
1471-2180
DOI
10.1186/s12866-024-03581-1
