2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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2-Oxoglutarate (2OG) oxygenases are validated agrochemical and human drug targets. The potential for modulating their activity with 2OG derivatives has not been explored, possibly due to concerns regarding selectivity. We report proof-of-principle studies demonstrating selective enhancement or inhibition of 2OG oxygenase activity by 2-oxo acids. Th...
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2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases
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TN_cdi_doaj_primary_oai_doaj_org_article_f65c6124dc4f4697b8a6aadeea9cfc56
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f65c6124dc4f4697b8a6aadeea9cfc56
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26673-2
