Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy
Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Deficiency of adenosine deaminase (ADA, EC3.5.4.4), a housekeeping enzyme intrinsic to the purine salvage pathway, leads to severe combined immunodeficiency (SCID) both in humans and mice. Lack of ADA results in the intracellular accumulation of toxic metabolites which have effects on T cell development and function. While untreated ADA-SCID is a f...
Alternative Titles
Full title
Metabolite and thymocyte development defects in ADA-SCID mice receiving enzyme replacement therapy
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_f65c7cd9d5074750a94e03ee0d0444ee
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_f65c7cd9d5074750a94e03ee0d0444ee
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-02572-w
